A Cryptographic Ensemble for Secure Third Party Data Analysis: Collaborative Data Clustering Without Data Owner Participation

This paper introduces the twin concepts Cryptographic Ensembles and Global Encrypted Distance Matrices (GEDMs), designed to provide a solution to outsourced secure collaborative data clustering. The cryptographic ensemble comprises: Homomorphic Encryption (HE) to preserve raw data privacy, while supporting data analytics; and Multi-User Order Preserving Encryption (MUOPE) to preserve the privacy of the GEDM. Clustering can therefore be conducted over encrypted datasets without requiring decryption or the involvement of data owners once encryption has taken place, all with no loss of accuracy. The GEDM concept is applicable to large scale collaborative data mining applications that feature horizontal data partitioning. In the paper DBSCAN clustering is adopted for illustrative and evaluation purposes. The results demonstrate that the proposed solution is both efficient and accurate while maintaining data privacy

Bi-allelic variants in HOPS complex subunit VPS41 cause cerebellar ataxia and abnormal membrane trafficking.

Membrane trafficking is a complex, essential process in eukaryotic cells responsible for protein transport and processing. Deficiencies in vacuolar protein sorting (VPS) proteins, key regulators of trafficking, cause abnormal intracellular segregation of macromolecules and organelles and are linked to human disease. VPS proteins function as part of complexes such as the homotypic fusion and vacuole protein sorting (HOPS) tethering complex, composed of VPS11, VPS16, VPS18, VPS33A, VPS39 and VPS41. The HOPS-specific subunit VPS41 has been reported to promote viability of dopaminergic neurons in Parkinson's disease but to date has not been linked to human disease. Here, we describe five unrelated families with nine affected individuals, all carrying homozygous variants in VPS41 that we show impact protein function. All affected individuals presented with a progressive neurodevelopmental disorder consisting of cognitive impairment, cerebellar atrophy/hypoplasia, motor dysfunction with ataxia and dystonia, and nystagmus. Zebrafish disease modelling supports the involvement of VPS41 dysfunction in the disorder, indicating lysosomal dysregulation throughout the brain and providing support for cerebellar and microglial abnormalities when vps41 was mutated. This provides the first example of human disease linked to the HOPS-specific subunit VPS41 and suggests the importance of HOPS complex activity for cerebellar function

Coronary artery bypass grafting following stent restenosis

Coronary artery bypass grafting (CABG) is the gold standard for treatment of patients with coronary artery disease. In recent years, a less invasive technique, percutaneous coronary intervention (PCI), has been increasingly used in clinical practice due to technical improvements, in particular the widespread use of drug-eluting stents (DES). However, clinical outcomes of these two approaches in treating coronary artery disease remain to be determined. This chapter provides an overview of the clinical benefi ts of CABG over PCI using coronary stenting. Hybrid approaches of combining CABG with PCI, and CABG following coronary stent restenosis are discussed, while computational hemodynamic modeling of CABG treatment strategy is highlighted